منابع مشابه
Long-Acting Thyroid Stimulator
Highly purified bovine TSH (thyroid-stimulating hormone) was labelled with 125I by using very low concentrations of chloramine-T. Human thyroid membranes prepared by discontinuous sucrose-density-gradient centrifugation were homogeneous on examination by electron microscopy. Incubation of radioiodinated TSH with the membranes showed that radioactivity could be bound to the membranes. Under the ...
متن کاملInhibition of long-acting thyroid stimulator by thyroid particulate fractions.
The long-acting thyroid stimulator (LATS), found uniquely in the serum of patients with Graves' disease, is closely associated with the immunoglobulin G (IgG) proteins of serum and is removed from serum by antibody to human IgG (2, 3). Since some IgG molecules function as antibodies, it seems possible that LATS is also an antibody. This possibility would be strengthened if LATS could be demonst...
متن کاملNeonatal hyperthyroidism and long-acting thyroid stimulator protector.
Neonatal hyperthyroidism has been thought to result from transplacental passage of long-acting thyroid stimulator (L.A.T.S.) from a mother with Graves's disease. A case is presented here in which no L.A.T.S. was detected in the mother or neonate but another immunoglobulin, L.A.T.S. protector, a specific human thyroid stimulator, was shown to be present in the mother's serum. This stimulator may...
متن کاملEffects of long-acting thyroid stimulator (LATS) and LATS protector on human thyroid adenyl cyclase activity.
The long-acting thyroid stimulator (LATS) has been thought to be responsible for the hyperthyroidism of Graves's disease. It is detected by its effect on the mouse thyroid gland but cannot be found in all patients with hyperthyroidism. In an attempt to clarify the problem of LATS-negative hyperthyroidism, serum was obtained from untreated patients and its effect in vitro on human thyroid tissue...
متن کاملAcute endocrine ophthalmopathy in a 12-year-old boy with long-acting thyroid stimulator.
The aetiology of ophthalmopathy associated with thyroid disease is unknown. Excessive secretion of pituitary thyrotropin (TSH) had been suggested as a cause of exophthalmos (thyrotropic) (Falconer and Alexander, 195I). However, assays for thyrotropic hormone in patients with endocrine ophthalmopathy failed to reveal an elevation of TSH in the blood either before or during the development of acu...
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ژورنال
عنوان ژورنال: Clinical Pharmacology & Therapeutics
سال: 1966
ISSN: 0009-9236
DOI: 10.1002/cpt196676788